Tag: cryo

Cryo-EM as a Stochastic Inverse Problem arXiv:2509.05541v1 Announce Type: new Abstract: Cryo-electron microscopy (Cryo-EM) enables high-resolution imaging of biomolecules, but structural heterogeneity remains a major challenge in 3D reconstruction. Traditional methods assume a discrete set of conformations, limiting their ability to recover continuous structural variability. In this work, we formulate cryo-EM reconstruction as a stochastic…