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Tag: treatment

  • Dimension-reduced outcome-weighted learning for estimating individualized treatment regimes in observational studies

    Dimension-reduced outcome-weighted learning for estimating individualized treatment regimes in observational studies arXiv:2601.06782v1 Announce Type: new Abstract: Individualized treatment regimes (ITRs) aim to improve clinical outcomes by assigning treatment based on patient-specific characteristics. However, existing methods often struggle with high-dimensional covariates, limiting accuracy, interpretability, and real-world applicability. We propose a novel sufficient dimension reduction approach that…

  • Detecting and Mitigating Treatment Leakage in Text-Based Causal Inference: Distillation and Sensitivity Analysis

    Detecting and Mitigating Treatment Leakage in Text-Based Causal Inference: Distillation and Sensitivity Analysis arXiv:2601.02400v1 Announce Type: cross Abstract: Text-based causal inference increasingly employs textual data as proxies for unobserved confounders, yet this approach introduces a previously undertheorized source of bias: treatment leakage. Treatment leakage occurs when text intended to capture confounding information also contains signals…

  • Identification and Estimation under Multiple Versions of Treatment: Mixture-of-Experts Approach

    Identification and Estimation under Multiple Versions of Treatment: Mixture-of-Experts Approach arXiv:2601.00287v1 Announce Type: cross Abstract: The Stable Unit Treatment Value Assumption (SUTVA) includes the condition that there are no multiple versions of treatment in causal inference. Though we could not control the implementation of treatment in observational studies, multiple versions may exist in the treatment.…

  • Arbitrated Indirect Treatment Comparisons

    Arbitrated Indirect Treatment Comparisons arXiv:2510.18071v1 Announce Type: new Abstract: Matching-adjusted indirect comparison (MAIC) has been increasingly employed in health technology assessments (HTA). By reweighting subjects from a trial with individual participant data (IPD) to match the covariate summary statistics of another trial with only aggregate data (AgD), MAIC facilitates the estimation of a treatment effect…

  • Kernel Treatment Effects with Adaptively Collected Data

    Kernel Treatment Effects with Adaptively Collected Data arXiv:2510.10245v1 Announce Type: new Abstract: Adaptive experiments improve efficiency by adjusting treatment assignments based on past outcomes, but this adaptivity breaks the i.i.d. assumptions that underpins classical asymptotics. At the same time, many questions of interest are distributional, extending beyond average effects. Kernel treatment effects (KTE) provide a…

  • Evaluating and Learning Optimal Dynamic Treatment Regimes under Truncation by Death

    Evaluating and Learning Optimal Dynamic Treatment Regimes under Truncation by Death arXiv:2510.07501v1 Announce Type: new Abstract: Truncation by death, a prevalent challenge in critical care, renders traditional dynamic treatment regime (DTR) evaluation inapplicable due to ill-defined potential outcomes. We introduce a principal stratification-based method, focusing on the always-survivor value function. We derive a semiparametrically efficient,…

  • Coupling Generative Modeling and an Autoencoder with the Causal Bridge

    Coupling Generative Modeling and an Autoencoder with the Causal Bridge arXiv:2509.25599v1 Announce Type: new Abstract: We consider inferring the causal effect of a treatment (intervention) on an outcome of interest in situations where there is potentially an unobserved confounder influencing both the treatment and the outcome. This is achievable by assuming access to two separate…

  • Causal Clustering for Conditional Average Treatment Effects Estimation and Subgroup Discovery

    Causal Clustering for Conditional Average Treatment Effects Estimation and Subgroup Discovery arXiv:2509.05775v1 Announce Type: new Abstract: Estimating heterogeneous treatment effects is critical in domains such as personalized medicine, resource allocation, and policy evaluation. A central challenge lies in identifying subpopulations that respond differently to interventions, thereby enabling more targeted and effective decision-making. While clustering methods…

  • Estimating Treatment Effects with Independent Component Analysis

    Estimating Treatment Effects with Independent Component Analysis arXiv:2507.16467v1 Announce Type: new Abstract: The field of causal inference has developed a variety of methods to accurately estimate treatment effects in the presence of nuisance. Meanwhile, the field of identifiability theory has developed methods like Independent Component Analysis (ICA) to identify latent sources and mixing weights from…

  • Self Balancing Neural Network: A Novel Method to Estimate Average Treatment Effect

    Self Balancing Neural Network: A Novel Method to Estimate Average Treatment Effect arXiv:2507.12818v1 Announce Type: new Abstract: In observational studies, confounding variables affect both treatment and outcome. Moreover, instrumental variables also influence the treatment assignment mechanism. This situation sets the study apart from a standard randomized controlled trial, where the treatment assignment is random. Due…

  • Robust estimation of heterogeneous treatment effects in randomized trials leveraging external data

    Robust estimation of heterogeneous treatment effects in randomized trials leveraging external data arXiv:2507.03681v1 Announce Type: new Abstract: Randomized trials are typically designed to detect average treatment effects but often lack the statistical power to uncover effect heterogeneity over patient characteristics, limiting their value for personalized decision-making. To address this, we propose the QR-learner, a model-agnostic…

  • It’s Hard to Be Normal: The Impact of Noise on Structure-agnostic Estimation

    It’s Hard to Be Normal: The Impact of Noise on Structure-agnostic Estimation arXiv:2507.02275v1 Announce Type: new Abstract: Structure-agnostic causal inference studies how well one can estimate a treatment effect given black-box machine learning estimates of nuisance functions (like the impact of confounders on treatment and outcomes). Here, we find that the answer depends in a…

  • TV-SurvCaus: Dynamic Representation Balancing for Causal Survival Analysis

    TV-SurvCaus: Dynamic Representation Balancing for Causal Survival Analysis arXiv:2505.01785v1 Announce Type: new Abstract: Estimating the causal effect of time-varying treatments on survival outcomes is a challenging task in many domains, particularly in medicine where treatment protocols adapt over time. While recent advances in representation learning have improved causal inference for static treatments, extending these methods…

  • Statistical Learning for Heterogeneous Treatment Effects: Pretraining, Prognosis, and Prediction

    Statistical Learning for Heterogeneous Treatment Effects: Pretraining, Prognosis, and Prediction arXiv:2505.00310v1 Announce Type: new Abstract: Robust estimation of heterogeneous treatment effects is a fundamental challenge for optimal decision-making in domains ranging from personalized medicine to educational policy. In recent years, predictive machine learning has emerged as a valuable toolbox for causal estimation, enabling more flexible…

  • Post Launch Evaluation of Policies in a High-Dimensional Setting

    Post Launch Evaluation of Policies in a High-Dimensional Setting arXiv:2501.00119v1 Announce Type: new Abstract: A/B tests, also known as randomized controlled experiments (RCTs), are the gold standard for evaluating the impact of new policies, products, or decisions. However, these tests can be costly in terms of time and resources, potentially exposing users, customers, or other…

  • When Is Heterogeneity Actionable for Personalization?

    When Is Heterogeneity Actionable for Personalization? arXiv:2411.16552v1 Announce Type: cross Abstract: Targeting and personalization policies can be used to improve outcomes beyond the uniform policy that assigns the best performing treatment in an A/B test to everyone. Personalization relies on the presence of heterogeneity of treatment effects, yet, as we show in this paper, heterogeneity…